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Open Access Article

International Journal of Genetics Frontiers. 2023; 4: (1) ; 1-5 ; DOI: 10.12208/j.ijgf.20230001.

Progress in the study of antitumor mechanism of isovanillin
异香兰素类化合物的生物活性研究进展

作者: 王镜超, 王明鑫智, 金成浩 *

黑龙江八一农垦大学生命科学技术学院 黑龙江大庆

*通讯作者: 金成浩,单位:黑龙江八一农垦大学生命科学技术学院 黑龙江大庆;

发布时间: 2023-03-14 总浏览量: 1146

摘要

异香兰素又称异香草醛,具有活泼的羟基和醛基,是合成多种活性药物、复杂天然产物的芳香烃类化合物。近年来,国内外研究者已将异香兰素作为重要原料合成多种医药中间体,其中包括第二态抑制剂磷酸二酯酶-4(Phosphodiesterase-4)、肾素抑制剂Aliskiren、肿瘤新血管生成抑制剂CombretastatinA-4、新一代抗生素santiagonamine等。本文将以异香兰素以及其作为原料合成的重要产物为对象,围绕其药理作用以及分子机制进行综述,为异香兰素的深入研究和开发利用提供新思路。

关键词: 异香兰素;生物活性;医药中间体;抗肿瘤

Abstract

Isovanillin, also known as isovanillin, has active hydroxyl groups and aldehyde groups, and is an aromatic hydrocarbon compound that synthesizes a variety of active drugs and complex natural products. In recent years, researchers at home and abroad have used isovanillin as an important raw material to synthesize a variety of pharmaceutical intermediates, including the second state inhibitor phosphodiesterase-4 (Phosphodiesterase-4), renin inhibitor Aliskiren, tumor neoangiogenesis inhibitor CombretastatinA-4, and a new generation of antibiotics santiagonamine. In this paper, we will review the pharmacological effects and molecular mechanisms of isovanillin and its synthesis as raw materials, so as to provide new ideas for the in-depth research, development and utilization of isovanillin.

Key words: Isovanillin; Biological activity; Pharmaceutical intermediates; Antitumor

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引用本文

王镜超, 王明鑫智, 金成浩, 异香兰素类化合物的生物活性研究进展[J]. 国际遗传前沿杂志, 2023; 4: (1) : 1-5.