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Open Access Article

International Journal of Genetics Frontiers. 2022; 3: (1) ; 10-12 ; DOI: 10.12208/j.ijgf.20220004.

A Case-Control Study of Cytochrome P450 Gene 1A1 and Types of Lung Cancer
细胞色素P450基因1A1与肺癌类型病例对照研究

作者: 李英 *

广东药科大学 广东广州

*通讯作者: 李英,单位:广东药科大学 广东广州;

发布时间: 2022-12-12 总浏览量: 51

摘要

目的 探讨分析肿瘤易感性标志物细胞色素P4501A1与肺癌的关联性。方法 在本次研究进行时,选择原发性肺癌患者共计60名,同时选择60名对照实验时间段设置在2021年4月至2022年6月。研究人员在所有患者入院后,由医务人员对其进行采血DNA提取并应用多聚合酶链反应-限制性片段长度多态性,对其细胞色素P4501A1进行检验,确定患者的基因型保护特征。结果 在本次研究结果中显示,鳞癌的发生与细胞色素P4501A1突变有明显关联(OR=2.76,P=0.011),吸烟与细胞色素P4501A1产生的联合作用,并没有发现与不同的肺癌类型有密切的关联。而针对不吸烟的患者,细胞色素P4501A1杂合型,可能是一个十分重要的保护因素(OR=0.16,P=0.033),能够在一定程度上降低磷癌的风险性。饮酒与细胞色素P4501A1突变型基因联合作用,会与鳞癌呈现密切相关性(OR=4.33,P=0.046)。而细胞色素P4501A1杂合型基因的联合作用与腺癌两者之间的关联较为密切(OR=22.01,P=0.007)。结论 在本次研究结果中显示细胞色素P4501A1突变型、基因型是肺癌的一个重要易感因素,相关研究人员可通过基因诊断的方式确定患者是否存在肺癌高危情况对于患者的后续治疗以及日常生活的管理来说,有十分积极的指导作用,对于提高人群的健康水平来说不可忽视。

关键词: 细胞色素;细胞色素P4501A1;肺癌;病例对照分析

Abstract

Objective To explore the correlation between tumor susceptibility marker cytochrome cytochrome P4501A1 and lung cancer. Method In this study, a total of 60 patients with primary lung cancer were selected, and 60 control subjects were selected. The time period of the experiment was set from April 2021 to June 2022. After all the patients were admitted to the hospital, medical staff extracted DNA from their blood and applied multiple polymerase chain reaction-restriction fragment length polymorphism to test their cytochrome P4501A1 to determine the genotype protection characteristics of the patients.
Results The results of this study showed that the occurrence of squamous cell carcinoma was significantly associated with the mutation of cytochrome P4501A1 (OR=2.76, P=0.011), and the combined effect of smoking and cytochrome P4501A1 was not found to be associated with different types of lung cancer are closely related. For non-smoking patients, cytochrome P4501A1 heterozygosity may be a very important protective factor (OR=0.16, P=0.033), which can reduce the risk of phosphorus cancer to a certain extent. The combined effects of alcohol consumption and cytochrome P4501A1 mutant gene are closely related to squamous cell carcinoma (OR=4.33, P=0.046). However, the combined effect of cytochrome P4501A1 heterozygous gene was closely related to adenocarcinoma (OR=22.01, P=0.007).
Conclusion   The results of this study show that cytochrome P4501A1 mutation and genotype are an important susceptibility factor for lung cancer. Relevant researchers can determine whether a patient has a high risk of lung cancer through genetic diagnosis. For the follow-up treatment of patients and daily life In terms of management, it has a very positive guiding role, which cannot be ignored in terms of improving the health of the population.

Key words: cytochrome; cytochrome P4501A1; lung cancer; case-control analysis

参考文献 References

[1] 檀廷飞. 肺癌患者细胞色素P450基因多态性与安罗替尼血药浓度及不良反应的相关性研究[D].安徽医科大学,2022.

[2] Lam V.K.,Scott R.J.,Billings P.,Cabebe E.,Young R.P.. Utility of incorporating a gene-based lung cancer risk test on uptake and adherence in a community-based lung cancer screening pilot study[J]. Preventive Medicine Reports,2021,23(prepublish).

[3] Li Meng,Li Anqi,He Ruiqing,Dang Wenhui,Liu Xinyu,Yang Tian,Shi Puyu,Bu Xiang,Gao Dan,Zhang Ning,Du Shuli,Jin Tianbo,Chen Mingwei. Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility.[J]. Cancer medicine,2019,8(10).

[4] 曹蕾,何冰,林佳,王宏戈,饶娟,刘英文,张雪梅. 细胞色素P450 2E1基因多态性与小细胞肺癌相关性分析[J]. 中华流行病学杂志,2013,34(10):1048-1049.

[5] 王方,杨海燕. 细胞色素P450 2E1基因RsaⅠ/PstⅠ位点多态性与中国人肺癌易感性关系的Meta分析[J]. 中华预防医学杂志,2010,(06):553-554.

[6] 顾艳斐,张宗德,张树才,郑素华,贾红彦,古淑香. 细胞色素P450基因多态性与肺癌易感性的相关性分析[J]. 中华医学杂志,2007,87(43):3064-3068.

[7] 王德全,陈思东,汪保国,周卫平. 广州地区182例汉族人细胞色素P450 1A1和2E1基因多态性与肺癌关系的病例对照研究[J]. 中国肺癌杂志,2006,(06):497-501.

[8] 胡毅玲,高杨,张桥. 细胞色素P450  1A1、2D6和谷胱甘肽硫转移酶基因多态性与肺癌易感性的研究[J]. 肿瘤,1998,(04):21-23.

引用本文

李英, 细胞色素P450基因1A1与肺癌类型病例对照研究[J]. 国际遗传前沿杂志, 2022; 3: (1) : 10-12.