International Journal of Genetics Frontiers. 2020; 1: (1) 5; 24-29 ; DOI: 10.12208/j.ijgf.20200005.
Interleukin-6 (-174 G/C) and Hepcidin HAMP (-582A/G) Gene Polymorphisms among Sudanese Patients with Anemia of Chronic Kidney Disease Treated with Erythropoietin 促红细胞生成素治疗苏丹慢性肾脏病贫血患者的白细胞介素-6（-174G/C）和铁调素HAMP（-582A/G）基因多态性
Objectives. This is a case controls study used to determine the frequency of Interleukin-6 (-174 G/C) and hepcidin HAMP (-582A/G) gene polymorphisms among Sudanese patients with anemia of chronic kidney disease treated with erythropoietin by using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR/RFLP). Results. Significantly decreased levels in RBCS profile: RBCs count, Hb and PCVin patients with CKD and RBCS profile were observed. The polymorphisms (SNP) of the IL-6 gene and hepcidin (HAMP) gene promoter in Sudanese patients with ACKD were showed. the IL-6 (-174G/C) (SNP) was present in the hepcidin HAMP (-582A/G) (SNP) AA genotype 70 (35%), AG 23 (11.5) and GG 7 (3.5%) in 100 patients dialysis dependent and AA 166 (41.5%), AG 34 (8.5%) and GG 0 (0%) in 200 control subjects, and the allele A are more frequent in patients affected by ACKD.