Objective To evaluate the value of DNATyper X19 kit in the forensic application. Methods In this study, we carried out a survey of genetic polymorphism from 374 Northern Chinese Han individuals. Results A total of 140 alleles were detected among the 18 X-STR loci from 374 Northern Chinese Han individuals, 228 haplotypes were detected from the 228 males, the diversity is 100%. No markers departed from Hardy-Weinberg equilibrium after applying Bonferroni’s correction for multiple testing (p=0.05/18), GATA31E08-DXS6797, DXS8377-DXS10079 were in linkage disequilibrium (LD) in this study (p=0.05/153). The polymorphism information content (PIC) was 0.434-0.908 and the discrimination power (DP) was 0.432-0.983. The combined discrimination power was 0.99999993 for male and 0.999999992 for female. The combined mean exclusion chance was 0.999993 in duo cases (CMECduo) and 0.999999994 in trio case (CMECtrio). Conclusion s DNATyper X19 kit showed potential value for complicated paternity cases.
Key words： Forensic Genetics, X Chromosome, X-STR
YU Zhengliang, CAI Huiju, MA Wenhua, MO Xiaoting, YAO Yiren, WANG Le, LIU Chao, ZHAO Xingchun, LI Wanshui, DNATyper X19试剂盒在中国北方汉族人的遗传多态性[J]. 国际遗传前沿杂志, 2020; 1: (1) : 5-11.