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Open Access Article

International Journal of Genetics Frontiers. 2020; 1: (1) 1; 1-4 ; DOI: 10.12208/j.ijgf.20200001.

Advance in DNA Methylation Research of Autism Spectrum Disorders
自闭症谱系障碍DNA甲基化研究进展

作者: Fang Wang, Jishui Zhang, Yilin Liu, Weixing Feng, Fang Fang*,

首都医科大学附属北京儿童医院神经内科,国家儿童保健中心

*通讯作者: Fang Fang,单位:首都医科大学附属北京儿童医院神经内科,国家儿童保健中心;

发布时间: 2020/6/17 11:25:23 总浏览量: 433

摘要

自闭症谱系障碍(ASD)是儿童常见的精神障碍,该病的病因尚不清楚。研究表明,遗传和环境因素在该疾病的发病机理中起着重要作用。表观遗传修饰在基因与环境相互作用的过程中至关重要。作为最常见的表观遗传修饰,近年来,DNA甲基化正逐渐成为自闭症谱系障碍病因研究的热点。

关键词: 自闭症谱系障碍;自闭症表观遗传修饰;DNA甲基化

Abstract

The autism spectrum disorder(ASD) is a common mental disorder in children. The etiology of this disease remains unclear. The studies show that the genetic and environmental factors play an important role in the pathogenesis of the disease. Epigenetic modification plays an important role in the process of gene and environment interaction. As the most common epigenetic modification, DNA methylation is becoming gradually a hot research topic of ASD etiology in recent years.

Key words: Autism spectrum disorder; Epigenetic modification; DNA methylation

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引用本文

Fang Wang, Jishui Zhang, Yilin Liu, Weixing Feng, Fang Fang, 自闭症谱系障碍DNA甲基化研究进展[J]. 国际遗传前沿杂志, 2020; 1: (1) : 1-4.